Defiled Rune/Affected Drops

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Item Enemy
Pre-Hardmode
Arkhalis Arkhalis Cosmic Elemental
Bezoar Bezoar Hornet, Moss Hornet, Toxic Sludge
Binoculars Binoculars Eye of Cthulhu
Black Lens Black Lens Demon Eye, Wandering Eye
Bladecrest Oathsword Bladecrest Oathsword Demon
Bone Pickaxe Bone Pickaxe Undead Miner
Bone Sword Bone Sword Skeleton
Bouncing Eyeball Bouncing Eyeball Drippler
Chain Knife Chain Knife Cave Bat
Clothier Voodoo Doll Clothier Voodoo Doll Angry Bones, Dark Caster
Demon Scythe Demon Scythe Demon
Depth Meter Depth Meter Cave Bat
Diving Helmet Diving Helmet Shark, Trasher
Enchanted Sword Enchanted Sword Cosmic Elemental
Flipper Flipper Moray Eel
Honeyed Goggles Honeyed Goggles Queen Bee
Hook Hook Piranha
Ink Bomb Ink Bomb Cuttlefish
Jellyfish Necklace Jellyfish Necklace Pink Jellyfish
Magma Stone Magma Stone Lava Bat
Mandible Blade Mandible Blade Antlion Charger
Nazar Nazar Cursed Skull
Obsidian Rose Obsidian Rose Fire Imp
Sky Glaze Sky Glaze Harpy
Starfury Starfury Cosmic Elemental
Waraxe Waraxe Skeleton
Hardmode
Adhesive Bandage Adhesive Bandage Angler Fish, Werewolf
Ancient Horn Ancient Horn Basilisk
Armor Polish Armor Polish Armored Skeleton
The Axe The Axe Plantera
Bananarang Bananarang Clown
Beam Sword Beam Sword Armored Skeleton
Blindfold Blindfold Corrupt Slime, Dark Mummy
Bone Feather Bone Feather Hardmode Dungeon enemies
Brain Scrambler (item) Brain Scrambler (item) Scutlix Rider
Broken Bat Wing Broken Bat Wing Vampire
Coin Gun Coin Gun Pirate Captain
Cutlass Cutlass Pirate Captain
Crystal Blade Crystal Blade Crystal Crawler
Death Sickle Death Sickle Reaper
Desert Spirit Lamp Desert Spirit Lamp Desert Spirit
Discount Card Discount Card Pirate Captain
Djinn's Curse Djinn's Curse Desert Spirit
Fast Clock Fast Clock Mummy, Pixie, Wraith
Fire Feather Fire Feather Red Devil
Frost Staff Frost Staff Ice Elemental, Icy Merman
Frozen Turtle Shell Frozen Turtle Shell Ice Tortoise
Giant Harpy Feather Giant Harpy Feather Harpy
Ice Sickle Ice Sickle Armored Viking, Ice Elemental, Ice Tortoise, Icy Merman
Inferno Fork Inferno Fork Diabolist
Keybrand Keybrand Hardmode Dungeon enemies
Kraken Kraken Paladin
Legendary items Legendary items Various Bosses
Lucky Coin Lucky Coin Pirate Captain
Megaphone Megaphone Dark Mummy, Green Jellyfish
Magic Quiver Magic Quiver Skeleton Archer
Magnet Sphere Magnet Sphere Hardmode Dungeon enemies
Marrow Marrow Skeleton Archer
Moon Charm Moon Charm Werewolf
Moon Stone Moon Stone Vampire
Paladin's Hammer Paladin's Hammer Paladin
Pirate Staff Pirate Staff Pirate Captain
Poison Staff Poison Staff Black Recluse
Psychotic Amulet Psychotic Amulet Possessed Armor
Rifle Scope Rifle Scope Skeleton Sniper
Rod of Discord Rod of Discord Chaos Elemental
Shadowbeam Staff Shadowbeam Staff Necromancer
Spectre Staff Spectre Staff Ragged Caster
Tattered Bee Wing Tattered Bee Wing Moss Hornet
Trifold Map Trifold Map Giant Bat
Uzi Uzi Angry Trapper
Vitamins Vitamins Corruptor, Floaty Gross
Wisp in a Bottle Wisp in a Bottle Hardmode Dungeon enemies
Yelets Yelets Giant Tortoise (after any Mechanical Boss has been defeated)