Permanent Power-ups

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Main article: Potion


Health Upgrades
Item Ingredients Effect Hearts
Blood Orange.png Blood Orange Life Fruit.png Life Fruit (5)
Essence of Chaos.png Essence of Chaos (5)
Essence of Eleum.png Essence of Eleum (5)
Essence of Sunlight.png Essence of Sunlight (5)
Soul of Light.png Soul of Light (10)
Soul of Night.png Soul of Night (10)
Permanently increases maximum life by 25
Bloodorangehearts.png
Miracle Fruit.png Miracle Fruit Life Fruit.png Life Fruit (5)
Living Shard.png Living Shard (10)
Aureus Cell.png Aureus Cell (5)
Stardust.png Stardust (20)
Permanently increases maximum life by 25
Miraclefruithearts.png
Elderberry.png Elderberry Life Fruit.png Life Fruit (5)
Uelibloom Bar.png Uelibloom Bar (10)
Luminite Bar.png Luminite Bar (10)
Unholy Essence.png Unholy Essence (20)
Permanently increases maximum life by 25
Elderberryhearts.png
Dragonfruit.png Dragonfruit Life Fruit.png Life Fruit (5)
Phantoplasm.gif Phantoplasm (5)
Cosmilite Bar.gif Cosmilite Bar (5)
Darksun Fragment.png Darksun Fragment (10)
Solar Fragment.png Solar Fragment (15)
Nightmare Fuel.png Nightmare Fuel (5)
Endothermic Energy.png Endothermic Energy (5)
Permanently increases maximum life by 25
Dragonfruithearts.png
Mana Upgrades
Item Ingredients Effect Stars
Comet Shard.png Comet Shard Meteorite Bar.png Meteorite Bar (10)
Fallen Star.png Fallen Star (50)
Stardust.png Stardust (150)
Permanently increases maximum mana by 50
Cometshardstars.png
Ethereal Core.png Ethereal Core Meteorite Bar.png Meteorite Bar (25)
Astral Bar.png Astral Bar (25)
Nebula Fragment.png Nebula Fragment (20)
Fallen Star.png Fallen Star (50)
Permanently increases maximum mana by 50
Etherealcorestars.png
Phantom Heart.png Phantom Heart Phantoplasm.gif Phantoplasm (100)
Ruinous Soul.png Ruinous Soul (10)
Permanently increases maximum mana by 50
Phantomheartstars.png
Rage Mode Upgrades
Item Drops from Effect
Mushroom Plasma Root.png Mushroom Plasma Root Crabulon.png Crabulon Permanently increases the Rage Mode damage buff by 15% / 60%.
Exclusive to Revengeance Mode and Death Mode.
Infernal Blood.png Infernal Blood Ravager.png Ravager Permanently increases the Rage Mode damage buff by 15% / 60%.
Exclusive to Revengeance Mode and Death Mode.
Red Lightning Container.png Red Lightning Container Bumblebirb.png Bumblebirb Permanently increases the Rage Mode damage buff by 15% / 60%.
Exclusive to Revengeance Mode and Death Mode.
Adrenaline Mode Upgrades
Item Drops from Effect
Electrolyte Gel Pack.png Electrolyte Gel Pack The Slime God.png The Slime God Permanently lowers the amount of time that the Adrenaline Meter takes to fill up by 10 seconds.
Exclusive to Revengeance Mode and Death Mode.
Starlight Fuel Cell.png Starlight Fuel Cell Astrum Aureus.png Astrum Aureus Permanently lowers the amount of time that the Adrenaline Meter takes to fill up by 10 seconds.
Exclusive to Revengeance Mode and Death Mode.
Ectoheart.png Ectoheart Polterghast.png Polterghast Permanently lowers the amount of time that the Adrenaline Meter takes to fill up by 5 seconds.
Exclusive to Revengeance Mode and Death Mode.
Other Upgrades
Item Drops from Effect
Demon Trophy.png Demon Trophy Wall of Flesh.png Wall of Flesh Permanently boosts enemy spawn rates in the current world by 1.25.
Celestial Onion.png Celestial Onion Moon Lord.png Moon Lord Permanently adds a sixth / seventh accessory slot.