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Permanent Power-ups

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Main article: Potion


Health Upgrades
Item Ingredients Effect Hearts
Blood OrangeBlood Orange Life FruitLife Fruit (5)
Soul of FrightSoul of Fright (5)
Soul of MightSoul of Might (5)
Soul of SightSoul of Sight (5)
Orange BloodrootOrange Bloodroot (1)
Blood OrbBlood Orb (10)
Permanently increases maximum life by 25
Bloodorangehearts.png
Miracle FruitMiracle Fruit Life FruitLife Fruit (5)
Living ShardLiving Shard (10)
Teal MushroomTeal Mushroom (1)
Life AlloyLife Alloy (5)

Trapper BulbTrapper Bulb (5)

Permanently increases maximum life by 25
Miraclefruithearts.png
ElderberryElderberry Life FruitLife Fruit (5)
Uelibloom BarUelibloom Bar (10)
Divine GeodeDivine Geode (10)
Unholy EssenceUnholy Essence (20)

Blue BerriesBlue Berries (1)

Permanently increases maximum life by 25
Elderberryhearts.png
DragonfruitDragonfruit Life FruitLife Fruit (5)
Sky Blue FlowerSky Blue Flower (1)
Darksun FragmentDarksun Fragment (10)
Solar FragmentSolar Fragment (15)
Nightmare FuelNightmare Fuel (5)
Endothermic EnergyEndothermic Energy (5)
Permanently increases maximum life by 25
Dragonfruithearts.png
Mana Upgrades
Item Ingredients Effect Stars
Enchanted StarfishEnchanted Starfish 10% chance to be fished up in the Surface at night Permanently increases maximum mana by 20.
Mana.png
Comet ShardComet Shard Meteorite BarMeteorite Bar (10)
Fallen StarFallen Star (50)
StardustStardust (150)
Permanently increases maximum mana by 50
Cometshardstars.png
Ethereal CoreEthereal Core Meteorite BarMeteorite Bar (25)
Astral BarAstral Bar (25)
Nebula FragmentNebula Fragment (20)
Fallen StarFallen Star (50)
Permanently increases maximum mana by 50
Etherealcorestars.png
Phantom HeartPhantom Heart PhantoplasmPhantoplasm (100)
Ruinous SoulRuinous Soul (10)
Permanently increases maximum mana by 50
Phantomheartstars.png
Rage Mode Upgrades
Item Drops from Effect
Mushroom Plasma RootMushroom Plasma Root CrabulonCrabulon Permanently increases the Rage Mode damage buff by 15%.
Exclusive to Revengeance Mode and Death Mode.
Infernal BloodInfernal Blood RavagerRavager Permanently increases the Rage Mode damage buff by 15%.
Exclusive to Revengeance Mode and Death Mode.
Red Lightning ContainerRed Lightning Container The DragonfollyThe Dragonfolly Permanently increases the Rage Mode damage buff by 15%.
Exclusive to Revengeance Mode and Death Mode.
Adrenaline Mode Upgrades
Item Drops from Effect
Electrolyte Gel PackElectrolyte Gel Pack The Slime GodThe Slime God Permanently lowers the amount of time that the Adrenaline Meter takes to fill up by 10 seconds.
Exclusive to Revengeance Mode and Death Mode.
Starlight Fuel CellStarlight Fuel Cell Astrum AureusAstrum Aureus Permanently lowers the amount of time that the Adrenaline Meter takes to fill up by 10 seconds.
Exclusive to Revengeance Mode and Death Mode.
EctoheartEctoheart PolterghastPolterghast Permanently lowers the amount of time that the Adrenaline Meter takes to fill up by 5 seconds.
Exclusive to Revengeance Mode and Death Mode.
Other Upgrades
Item Drops from Effect
Demon TrophyDemon Trophy Wall of FleshWall of Flesh Permanently boosts enemy spawn rates in the current world by 1.25.
Hermit's Box of One Hundred MedicinesHermit's Box of One Hundred Medicines Wall of FleshWall of Flesh Permanently makes the player respawn with full health. Non-consumable. Can be toggled.
Celestial OnionCelestial Onion Moon LordMoon Lord Permanently adds a sixth / seventh accessory slot.